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Article

Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.

Cellular immunology - 1 May 2001

Frauwirth K, Shastri N

Abstract excerpt

The invariant chain (Ii) is a key player in regulating the MHC Class II antigen presentation pathway. Here we used site-directed mutagenesis to identify functionally important regions of the invariant chain in regulating antigen presentation function in transfected cells. Mutation of Ii residues 42-53 caused a defect in the presentation of the ovalbumin 247-265/A(k) epitope, but not in the inhibition of...

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Source

Identifiers

PMID: 11446742
DOI: 10.1006/cimm.2001.1796

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation.PMID 11446742Read ↗

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.Semantic proximity Read ↗

Expression of invariant chain can cause an allele-dependent increase in the surface expression of MHC class I molecules.Semantic proximity Read ↗

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.Semantic proximity Read ↗

MHC class II-associated invariant chain contains a sorting signal for endosomal compartmentsSemantic proximity Read ↗

Association of the Invariant Chain with Major Histocompatibility Complex Class I Molecules Directs Trafficking to Endocytic CompartmentsSemantic proximity Read ↗

Structural requirements for major histocompatibility complex class II invariant chain endocytosis and lysosomal targeting.Semantic proximity Read ↗

Identification of residues in the class II-associated Ii peptide (CLIP) region of invariant chain that affect efficiency of MHC class II-mediated antigen presentation in an allele-dependent manner.Semantic proximity Read ↗

Mutations in specific I-A(k) alpha(2) and beta(2) domain residues affect surface expression.Semantic proximity Read ↗

Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production.Semantic proximity Read ↗

Posttranslational regulation of I-Ed by affinity for CLIP.Semantic proximity Read ↗

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties.Semantic proximity Read ↗

The transmembrane domain and luminal C-terminal region independently support invariant chain trimerization and assembly with MHCII into nonamers.Semantic proximity Read ↗

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