Article
CD8+ T cell recognition of an endogenously processed epitope is regulated primarily by residues within the epitope.
The Journal of experimental medicine - 1 Nov 1992
Hahn Y S, Hahn C S, Braciale V L, Braciale T J, Rice C M
Abstract excerpt
Cytotoxic T lymphocytes (CTL) recognize short antigenic peptides associated with cell surface class I major histocompatibility complex (MHC) molecules. This association presumably occurs between newly synthesized class I MHC molecules and peptide fragments in a pre-Golgi compartment. Little is known about the factors that regulate the formation of these antigenic peptide fragments within the cell. To examine the...
Topics
- Amino Acid Sequence
- Animals
- CD8 Antigens
- Epitopes
- Molecular Sequence Data
- Mutation
- Structure-Activity Relationship
- T-Lymphocytes
- T-Lymphocytes, Cytotoxic