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Article

Mutation of a single conserved residue in VH complementarity-determining region 2 results in a severe Ig secretion defect.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2001

Wiens G D, Lekkerkerker A, Veltman I, Rittenberg M B

Abstract excerpt

During an immune response, somatic mutations are introduced into the VH and VL regions of Ig chains. The consequences of somatic mutation in highly conserved residues are poorly understood. Ile51 is present in 91% of murine VH complementarity-determining region 2 sequences, and we demonstrate that single Ile51-->Arg or Lys substitutions in the PCG1-1 Ab are sufficient to severely reduce Ig secretion (1-3% of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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PMID: 11490003
DOI: 10.4049/jimmunol.167.4.2179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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