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Article

Structural definition by antibody engineering of an idiotypic determinant.

Protein engineering - 1 May 1990

Sollazzo M, Castiglia D, Billetta R, Tramontano A, Zanetti M

Abstract excerpt

Using computer-aided techniques for predicting molecular structure, we constructed an atomic model of the variable domain of a murine anti-thyroglobulin antibody whose immunodominant idiotypic determinant (Id62) was mapped by site-directed mutagenesis and immunochemical analysis. We previously showed that under experimental conditions this idiotype activates anti-idiotypic B cells and T cells, and modulates the...

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PMID: 2115164
DOI: 10.1093/protein/3.6.531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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