Structural definition by antibody engineering of an idiotypic determinant.

doi:10.1093/protein/3.6.531

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Article

Structural definition by antibody engineering of an idiotypic determinant.

Protein engineering - 1 May 1990

Sollazzo M, Castiglia D, Billetta R, Tramontano A, Zanetti M

Abstract excerpt

Using computer-aided techniques for predicting molecular structure, we constructed an atomic model of the variable domain of a murine anti-thyroglobulin antibody whose immunodominant idiotypic determinant (Id62) was mapped by site-directed mutagenesis and immunochemical analysis. We previously sh...

Topics

Amino Acid Sequence
Animals
Antibodies
Base Sequence
Cell Line
Computer Simulation
DNA
Humans
Immunoglobulin Idiotypes
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Molecular Sequence Data

Mutation

Protein Conformation

Protein Engineering

Thyroglobulin

Source

Open in PubMed

Identifiers

PMID: 2115164
DOI: 10.1093/protein/3.6.531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2115164-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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