Article
T cell recognition of somatically-generated Ab diversity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1994
Eyerman M C, Wysocki L
Abstract excerpt
During an immune response, specific Abs and B cells that are infrequently represented in the preimmune repertoire become amplified to abundance. Novel structures are also created through the physiological process of somatic hypermutation in Ab genes. This presents a challenge for T cell self-tole...
Topics
- Amino Acid Sequence
- Animals
- Antibody Diversity
- Histocompatibility Antigens Class II
- Hybridomas
- Immunoglobulin Variable Region
- Mice
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- T-Lymphocytes