Article
T cell recognition of somatically-generated Ab diversity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Feb 1994
Eyerman M C, Wysocki L
Abstract excerpt
During an immune response, specific Abs and B cells that are infrequently represented in the preimmune repertoire become amplified to abundance. Novel structures are also created through the physiological process of somatic hypermutation in Ab genes. This presents a challenge for T cell self-tolerance, because many potential V region epitopes are either rare or nonexistent during the maturation of the T cell...
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