Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG.

doi:10.1016/1074-7613(95)90007-1

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Article

Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG.

Immunity - 1 Jun 1995

Kaloff C R, Haas I G

Abstract excerpt

The first constant domain (CH1) of immunoglobulin heavy (H) chains is essential for BiP-mediated retention of unassembled H chains in the endoplasmic reticulum (ER). Here, we demonstrated that both wild-type and a mutant gamma chain lacking the CH1 domain bind BiP when they are reduced in vivo. However, only oxidized mutant H chain dimers are released from BiP interaction, whereas oxidized wild-type gamma chain...

Topics

Animals
Antibody-Producing Cells
Binding Sites, Antibody
Blotting, Western
Carrier Proteins
Cell Line
Electrophoresis, Polyacrylamide Gel
Genetic Vectors
Immunoglobulin G
Immunoglobulin Heavy Chains
Immunoglobulin Light Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mutation

Precipitin Tests

Protein Conformation

Protein Folding

Transfection

Source

Open in PubMed

Identifiers

PMID: 7796296
DOI: 10.1016/1074-7613(95)90007-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7796296-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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