Expression of monovalent fragments derived from a human IgM autoantibody in E. coli. The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity.

doi:10.1016/S0171-2985(11)80427-4

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Article

Expression of monovalent fragments derived from a human IgM autoantibody in E. coli. The input of the somatically mutated CDR1/CDR2 and of the CDR3 into antigen binding specificity.

Immunobiology - 1 Aug 1995

Jahn S, Roggenbuck D, Niemann B, Ward E S

Abstract excerpt

A hybridoma producing a polyspecific human monoclonal IgM antibody (named CB03) has been derived from a fusion of mouse myeloma cells with human spleen lymphocytes obtained from an autoimmune patient suffering from chronic idiopathic thrombocytopenia. The antibody was found to be encoded by somat...

Topics

Amino Acid Sequence
Antibody Specificity
Autoantibodies
Base Sequence
Binding Sites, Antibody
Escherichia coli
Genetic Vectors
Humans
Immunoglobulin Fab Fragments
Immunoglobulin M
Immunoglobulin Variable Region
Molecular Sequence Data
Mutation
Peptide Fragments
Recombinant Proteins

Source

Open in PubMed

Identifiers

PMID: 8522357
DOI: 10.1016/S0171-2985(11)80427-4

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8522357-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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