Article
Predicted complementarity determining regions of the T cell antigen receptor determine antigen specificity.
The EMBO journal - 1 Mar 1995
Katayama C D, Eidelman F J, Duncan A, Hooshmand F, Hedrick S M
Abstract excerpt
The antigen receptor on T cells (TCR) has been predicted to have a structure similar to a membrane-anchored form of an immunoglobulin F(ab) fragment. Virtually all of the conserved amino acids that are important for inter- and intramolecular interactions in the VH-VL pair are also conserved in th...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Columbidae
- Conserved Sequence
- Cytochrome c Group
- Epitopes
- H-2 Antigens
- Immunoglobulins
- L Cells
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Receptors, Antigen, T-Cell, alpha-beta