Article
The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies.
Proceedings of the National Academy of Sciences of the United States of America - 28 Apr 1998
Ditzel H J, Rosenkilde M M, Garred P, Wang M, Koefoed K, Pedersen C, Burton D R, Schwartz T W
Abstract excerpt
The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Delta32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface. CCR5Delta32 homozygous individuals are apparently normal but resistant to infection with R5 HIV-1. In two...
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