Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple nonfunctional alleles of CCR5 are frequent in various human populations.

Blood - 1 Sept 2000

Blanpain C, Lee B, Tackoen M, Puffer B, Boom A, Libert F, Sharron M, Wittamer V, Vassart G, Doms R W, Parmentier M

Abstract excerpt

CCR5 is the major coreceptor for macrophage-tropic strains of the human immunodeficiency virus type I (HIV-1). Homozygotes for a 32-base pair (bp) deletion in the coding sequence of the receptor (CCR5Delta32) were found to be highly resistant to viral infection, and CCR5 became, therefore, one of the paradigms illustrating the influence of genetic variability onto individual susceptibility to infectious and other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Chemokine CCL3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemokine CCL4

Share to HIV Envelope Protein gp120

Share to Iodine Radioisotopes

Share to Macrophage Inflammatory Proteins

Share to Radioligand Assay

Share to Receptors, CCR5

Source

Identifiers

PMID: 10961858

Genes

CCR5
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple nonfunctional alleles of CCR5 are frequent in various human populations.PMID 10961858Read ↗

Novel alleles of the chemokine-receptor gene CCR5.Semantic proximity Read ↗

CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro.Semantic proximity Read ↗

Chemokine receptor CCR5 genotype influences the kinetics of human immunodeficiency virus type 1 infection in human PBL-SCID mice.Semantic proximity Read ↗

Variants of CCR5, which are permissive for HIV-1 infection, show distinct functional responses to CCL3, CCL4 and CCL5.Semantic proximity Read ↗

Distribution of the CCR5 gene 32 base pair deletion and SDF1-3'A variant in healthy individuals from different populations.Semantic proximity Read ↗

Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population.Semantic proximity Read ↗

Chemokine receptor allelic polymorphisms: relationships to HIV resistance and disease progression.Semantic proximity Read ↗

Heterozygous defect in HIV-1 coreceptor CCR5 and chemokine production.Semantic proximity Read ↗

Persistence of dual-tropic HIV-1 in an individual homozygous for the CCR5 Delta 32 allele.Semantic proximity Read ↗

Distribution of the mutated delta 32 allele of the CCR5 gene in a Sicilian population.Semantic proximity Read ↗

Homozygous delta 32 deletion of the CCR-5 chemokine receptor gene in an HIV-1-infected patient.Semantic proximity Read ↗

Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.