Article
CCR5 Expression on Cells from HLA-Matched Unrelated Marrow Donors and Graft-versus-Host Disease
13 Jul 2009
Abstract excerpt
Graft-versus-host disease (GVHD) is a common complication that is caused by donor T cells following allogeneic hematopoietic cell transplant. Recently, the functional state of T cells has been characterized by their chemokine receptor expression pattern [1]. T cells expressing chemokine receptor CCR5 contribute to the rejection of solid organ allografts [2] and development of murine GVHD [3-5]. A nonfunctional...
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