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Article

Genetic and functional analysis of R5X4 human immunodeficiency virus type 1 envelope glycoproteins derived from two individuals homozygous for the CCR5delta32 allele.

Journal of virology - 1 Apr 2006

Gray Lachlan, Churchill Melissa J, Keane Niamh, Sterjovski Jasminka, Ellett Anne M, Purcell Damian F J, Poumbourios Pantelis, Kol Chenda, Wang Bin, Saksena Nitin K, Wesselingh Steven L, Price Patricia, French Martyn, Gabuzda Dana, Gorry Paul R

Abstract excerpt

We characterized human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins (Env) isolated from two HIV-1-infected CCR5delta32 homozygotes. Envs from both subjects used CCR5 and CXCR4 for entry into transfected cells. Most R5X4 Envs were lymphocyte-tropic and used CXCR4 exclusively for en...

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Source

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Identifiers

PMID: 16537640
DOI: 10.1128/JVI.80.7.3684-3691.2006
PMCID: PMC1440368

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16537640-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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