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Article

CCR5Delta32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivo.

Journal of virology - 1 Aug 2007

Agrawal Lokesh, Jin Qingwen, Altenburg Jeff, Meyer L, Tubiana R, Theodorou Ioannis, Alkhatib Ghalib

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) infection of individuals carrying the two alleles of the CCR5Delta32 mutation (CCR5(-/-)) has rarely been reported, but how the virus overcomes the CCR5Delta32 protective effect in these cases has not been delineated. We have investigated this in 6 infected (HIV(+)) and 25 HIV(-) CCR5(-/-) individuals. CD4(+) T lymphocytes isolated from HIV(-) CCR5(-/-) peripheral blood...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17522201
DOI: 10.1128/JVI.00068-07
PMCID: PMC1951285

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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CCR5Delta32 protein expression and stability are critical for resistance to human immunodeficiency virus type 1 in vivo.PMID 17522201Read ↗

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