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Article

Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.

Immunological investigations - 1 Jan 2009

Ahlenstiel Golo, Woitas Rainer P, Iwan Agathe, Nattermann Jacob, Feldmann Georg, Rockstroh Jürgen K, Oldenburg Johannes, Kupfer Bernd, Sauerbruch Tilman, Spengler Ulrich

Abstract excerpt

In hepatitis C virus (HCV) infection antiviral T cells express the CC chemokine receptor 5 (CCR5). Their recruitment to the liver is an important step in the immune response. A 32 base pair deletion in the CCR5 gene leads to reduced expression and total loss of CCR5 in CCR5-Delta32 heterozygous and homozygous subjects, respectively. However, the role of this mutation for antiviral immunity remains unclear. Here,...

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Share to Chemotaxis, Leukocyte
Share to Hemophilia A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis C, Chronic

Share to Interferon-gamma

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Share to Receptors, CCR5

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Source

Identifiers

PMID: 19811439
DOI: 10.1080/08820130902832035

Genes

CCR5
CCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of the CCR5-Delta32 mutation on hepatitis C virus-specific immune responses in patients with haemophilia.PMID 19811439Read ↗

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