Article
CC chemokine receptor 5 and renal-transplant survival.
Lancet (London, England) - 2 Jun 2001
Fischereder M, Luckow B, Hocher B, Wüthrich R P, Rothenpieler U, Schneeberger H, Panzer U, Stahl R A, Hauser I A, Budde K, Neumayer H, Krämer B K, Land W, Schlöndorff D
Abstract excerpt
BACKGROUND: About 1% of white populations are homozygous carriers of an allele of the gene for the CC chemokine receptor 5 (CCR5) with a 32 bp deletion (CCR5Delta32), which leads to an inactive receptor. During acute and chronic transplant rejection, ligands for CCR5 are upregulated, and the graft is infiltrated by CCR5-positive mononuclear cells. We therefore investigated the influence of CCR5Delta32 on...
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