Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.

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Article

Isolation of macrophage-like cell mutants resistant to the cytotoxic effect of oxidized low density lipoprotein.

Journal of lipid research - 1 Mar 1998

Hakamata H, Miyazaki A, Sakai M, Matsuda H, Suzuki H, Kodama T, Horiuchi S

Abstract excerpt

A high concentration of oxidized low density lipoprotein (Ox-LDL) showed a cytotoxic effect on mouse macrophage-derived J774 cells. Mutant cells were selected from these cells that were resistant to the cytotoxic effect of Ox-LDL. One mutant form, named JO21b cells, was characterized in the prese...

Topics

Animals
Blotting, Northern
Cell Death
Cell Line
Drug Resistance
Endocytosis
Ketocholesterols
Lipoproteins, LDL
Lysophosphatidylcholines
Macrophages
Macrophages, Peritoneal
Membrane Proteins
Mice
Mice, Knockout
Mutation
Peroxides
RNA, Messenger
Receptors, Immunologic

Source

Open in PubMed

Identifiers

PMID: 9548582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9548582-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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