Intracellular killing of Listeria monocytogenes in the J774.1 macrophage-like cell line and the lipopolysaccharide (LPS)-resistant mutant LPS1916 cell line defective in the generation of reactive oxygen intermediates after LPS treatment.

Abstract excerpt

Listeria monocytogenes is a facultative intracellular pathogen and survives within phagocytic cells by escaping from phagosomes into the cytoplasm. It has been reported that, in vivo, L. monocytogenes is effectively eliminated through cell-mediated immunity, especially by macrophages which have been immunologically activated by cytokines such as gamma interferon (IFN-gamma). However, this killing mechanism for L....

Topics

• Animals
• Arginine
• Cell Division
• Cells, Cultured
• Drug Interactions
• Drug Resistance, Microbial
• Hemolysis
• Interferon-gamma
• Lipopolysaccharides
• Listeria monocytogenes