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Article

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1 Oct 1996

Abstract excerpt

Nitric oxide (NO) generation initiates apoptotic cell death in different experimental systems. In RAW 264.7 macrophages the appearance of typical apoptotic markers is linked to inducible NO synthase induction. Mechanistically, accumulation of tumour suppressor p53 precedes apoptotic DNA fragmentation. With the use of S-nitroglutathione (GSNO) we correlated a dose-dependent p53 up-regulation to DNA fragmentation...

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PMID: 8870682
DOI: 10.1042/bj3190299

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