Defect in the induction of nitric oxide synthase by lipopolysaccharide (LPS) in an LPS-resistant mutant of a murine macrophage-like cell line, J774.1.

Abstract excerpt

Nitric oxide (.NO)-generating activity was examined in a lipopolysaccharide (LPS)-resistant mutant of a murine macrophage-like cell line, J774.1, treated with LPS or LPS and interferon-gamma (IFN-gamma). This mutant, an LPS1916 cell line, showed no NO2- accumulation in the culture medium, and no expression of NOS activity in the cell extract, .NO synthase (NOS(II)) protein or NOS(II) mRNA on treatment with up to...

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