Defect in the induction of nitric oxide synthase by lipopolysaccharide (LPS) in an LPS-resistant mutant of a murine macrophage-like cell line, J774.1.

doi:10.1248/bpb.21.673

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Article

Defect in the induction of nitric oxide synthase by lipopolysaccharide (LPS) in an LPS-resistant mutant of a murine macrophage-like cell line, J774.1.

Biological & pharmaceutical bulletin - 1 Jul 1998

Noda T, Amano F

Abstract excerpt

Nitric oxide (.NO)-generating activity was examined in a lipopolysaccharide (LPS)-resistant mutant of a murine macrophage-like cell line, J774.1, treated with LPS or LPS and interferon-gamma (IFN-gamma). This mutant, an LPS1916 cell line, showed no NO2- accumulation in the culture medium, and no...

Topics

Animals
Cell Line
Drug Resistance
Enzyme Induction
Interferon-gamma
Lipopolysaccharides
Macrophages
Mice
Mutation
Nitric Oxide
Nitric Oxide Synthase
Nitric Oxide Synthase Type II
RNA, Messenger

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