Isolation of a lipopolysaccharide (LPS)-resistant mutant, with defective LPS binding, of cultured macrophage-like cells.

Article

Isolation of a lipopolysaccharide (LPS)-resistant mutant, with defective LPS binding, of cultured macrophage-like cells.

The Journal of biological chemistry - 25 Apr 1990

Hara-Kuge S, Amano F, Nishijima M, Akamatsu Y

Abstract excerpt

Lipopolysaccharide (LPS)-resistant mutants which did not respond to LPS were isolated from a macrophage-like mouse cell line, J774.1. Unlike the parental J774.1 cells, these mutants grew even in LPS added medium as well as in normal growth medium without any morphological changes. Assay of 125I-L...

Topics

Animals
Cell Line
Drug Resistance
Gram-Negative Bacteria
Kinetics
Lipopolysaccharide Receptors
Lipopolysaccharides
Macrophages
Molecular Structure
Mutation
Receptors, Immunologic

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