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Article

Reduced expression of the macrophage scavenger receptors in macrophage-like cell mutants resistant to brefeldin A.

Biochemical and biophysical research communications - 4 Feb 1998

Ding Y, Hakamata H, Matsuda H, Kawano T, Kawasaki T, Miyazaki A, Horiuchi S

Abstract excerpt

Brefeldin A (BFA)-resistant mutants, JB15, JB23 and JB33, were isolated from mutagenized murine macrophage-like (J774) cells and their modified low density lipoprotein (LDL) metabolism was studied. When JB23 cells, the most resistant clone, were incubated with acetylated LDL, intracellular accumulation of cholesteryl esters (CE) was reduced by 31% as compared with J774 cells. The cell-association of...

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PMID: 9473518
DOI: 10.1006/bbrc.1997.8036

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