Article
Cytotoxic effect of oxidized low density lipoprotein on macrophages.
Journal of atherosclerosis and thrombosis - 1 Jan 1998
Hakamata H, Miyazaki A, Sakai M, Sakamoto Y I, Horiuchi S
Abstract excerpt
Macrophage or macrophage-derived foam cell death is one of the characteristic events in the development of cell-poor lipid-rich cores of the advanced atherosclerotic plaques. Although the in vivo mechanism for the death of macrophages is unclear, one possible candidate for the agent which induces macrophage cell death is oxidized low density lipoprotein (Ox-LDL). To investigate the mechanism of Ox-LDL-induced...
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