Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPS-binding.

doi:10.1093/oxfordjournals.jbchem.a124631

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Article

Identification of a biochemical lesion, and characteristic response to lipopolysaccharide (LPS) of a cultured macrophage-like cell mutant with defective LPS-binding.

Journal of biochemistry - 1 Nov 1994

Nishijima M, Hara-Kuge S, Takasuka N, Akagawa K, Setouchi M, Matsuura K, Yamamoto S, Akamatsu Y

Abstract excerpt

We have previously isolated a lipopolysaccharide (LPS)-resistant mutant (named LR-9) of a cultured macrophage-like cell line, J774.1. This mutant had defective LPS binding [Hara-Kuge, S., Amano, F., Nishijima, M., and Akamatsu, Y. (1990) J. Biol. Chem. 265, 6606-6610]. In this study, we found that: (1) LPS-binding to parental J774.1 cells was dependent on a serum factor with a molecular weight of about 60 kDa,...

Topics

Acute-Phase Proteins
Antigens, CD
Antigens, Differentiation, Myelomonocytic
Arachidonic Acid
Benzoquinones
Carrier Proteins
Cell Line
Lactams, Macrocyclic
Lipopolysaccharide Receptors
Lipopolysaccharides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mutation

Phosphatidylinositol Diacylglycerol-Lyase

Phosphoinositide Phospholipase C

Phosphoric Diester Hydrolases

Quinones

Rifabutin

Signal Transduction

Source

Open in PubMed

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PMID: 7534758
DOI: 10.1093/oxfordjournals.jbchem.a124631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7534758-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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