Article
oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function.
Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 1997
Humbert P O, Corcoran L M
Abstract excerpt
Targeted mutation of the gene for the Oct-2 transcription factor in mice caused neonatal lethality and abrogated mitogen-induced proliferation and differentiation of mature B lymphocytes in vitro. Here we show that Oct-2 is required for normal humoral responses upon immunization with T cell-depen...
Topics
- Animals
- Antibody Formation
- B-Lymphocytes
- Cell Differentiation
- Cell Division
- Cell Lineage
- Cell Survival
- DNA-Binding Proteins
- Immunosuppression Therapy
- Mice
- Mice, SCID
- Mutagenesis
- Octamer Transcription Factor-2
- Peritoneum
- Phenotype
- T-Lymphocytes
- Transcription Factors