Article
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.
Molecular and cellular biology - 1 Dec 2001
Zhu J W, Field S J, Gore L, Thompson M, Yang H, Fujiwara Y, Cardiff R D, Greenberg M, Orkin S H, DeGregori J
Abstract excerpt
E2F activity is critical for the control of the G(1) to S phase transition. We show that the combined loss of E2F1 and E2F2 results in profound effects on hematopoietic cell proliferation and differentiation, as well as increased tumorigenesis and decreased lymphocyte tolerance. The loss of E2F1 and E2F2 impedes B-cell differentiation, and hematopoietic progenitor cells in the bone marrow of mice lacking E2F1 and...
Topics
- Age Factors
- Animals
- Antigens
- Blotting, Western
- Bromodeoxyuridine
- Cell Cycle Proteins
- Cell Differentiation
- Cell Division
- Cells, Cultured
- DNA-Binding Proteins
- E2F Transcription Factors