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Article

Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.

The EMBO journal - 1 Jul 1993

Feldhaus A L, Klug C A, Arvin K L, Singh H

Abstract excerpt

The Oct-2 protein is a tissue-specific POU-homeodomain transcription factor. It has been considered to represent a developmental regulator of immunoglobulin gene expression by virtue of its interaction with a functionally essential octamer element found in immunoglobulin gene promoters. This prop...

Topics

Alleles
Animals
B-Lymphocytes
Cell Line
Cells, Cultured
DNA-Binding Proteins
Gene Expression
Genes, Immunoglobulin
Mice
Mutation
Octamer Transcription Factor-2
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Transfection

Source

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Identifiers

PMID: 8334992
DOI: 10.1002/j.1460-2075.1993.tb05937.x
PMCID: PMC413526

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8334992-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.PMID 8334992Read ↗

Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.Semantic proximity Read ↗

Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.Semantic proximity Read ↗

B cell development and immunoglobulin transcription in Oct-1-deficient mice.Semantic proximity Read ↗

Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.Semantic proximity Read ↗

oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function.Semantic proximity Read ↗

The B-Cell Specific Transcription Factor, Oct-2, Promotes Epstein-Barr Virus Latency by Inhibiting the Viral Immediate-Early Protein, BZLF1Semantic proximity Read ↗

A variant octamer motif in a Xenopus H2B histone gene promoter is not required for transcription in frog oocytes.Semantic proximity Read ↗

Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells.Semantic proximity Read ↗

The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter.Semantic proximity Read ↗

Transcription factor Oct‐2A contains functionally redundant activating domains and works selectively from a promoter but not from a remote enhancer position in non‐lymphoid (HeLa) cells.Semantic proximity Read ↗

Molecular Cloning, Genetic Mapping, and Developmental Expression of Bovine POU5F11Semantic proximity Read ↗

A two-base change in a POU factor-binding site switches pituitary-specific to lymphoid-specific gene expression.Semantic proximity Read ↗

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