Article
Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.
Oncogene - 6 Mar 1997
Carrozza M L, Jacobs H, Acton D, Verma I, Berns A
Abstract excerpt
We have examined the role of the AP-1 transcription factor on thymocyte maturation and thymus architecture by overexpressing FosB2 in transgenic mice. FosB2 is a naturally occurring splice variant of the FosB2 gene, encoding a truncated protein which lacks two domains necessary for transcriptiona...
Topics
- Age Factors
- Animals
- Bone Marrow Cells
- Bone Marrow Transplantation
- CD3 Complex
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cell Division
- Female
- Flow Cytometry
- Male
- Mice
- Mice, Transgenic
- Phenotype
- Proto-Oncogene Proteins c-fos
- Spleen
- T-Lymphocyte Subsets
- Thymus Gland