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Article

Overexpression of the FosB2 gene in thymocytes causes aberrant development of T cells and thymic epithelial cells.

Oncogene - 6 Mar 1997

Carrozza M L, Jacobs H, Acton D, Verma I, Berns A

Abstract excerpt

We have examined the role of the AP-1 transcription factor on thymocyte maturation and thymus architecture by overexpressing FosB2 in transgenic mice. FosB2 is a naturally occurring splice variant of the FosB2 gene, encoding a truncated protein which lacks two domains necessary for transcriptional activation. The expression of FosB2 in the thymocytes severely affected their maturation and the structure of the...

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PMID: 9070657
DOI: 10.1038/sj.onc.1200921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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