Article
Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jul 1992
Hsieh C S, Heimberger A B, Gold J S, O'Garra A, Murphy K M
Abstract excerpt
To address the mechanisms controlling T helper (Th) phenotype development, we used DO10, a transgenic mouse line that expresses the alpha beta T-cell receptor from an ovalbumin-reactive T hybridoma, as a source of naive T cells that can be stimulated in vitro with ovalbumin peptide presented by d...
Topics
- Animals
- Antigen-Presenting Cells
- Cell Differentiation
- Dose-Response Relationship, Drug
- Immunization
- Interferon-gamma
- Interleukin-10
- Interleukin-4
- Mice
- Mice, Transgenic
- Phenotype
- Receptors, Antigen, T-Cell, alpha-beta
- T-Lymphocyte Subsets
- T-Lymphocytes, Helper-Inducer