B cell development and immunoglobulin transcription in Oct-1-deficient mice.

doi:10.1073/pnas.0307304101

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Article

B cell development and immunoglobulin transcription in Oct-1-deficient mice.

Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2004

Wang Victoria E H, Tantin Dean, Chen Jianzhu, Sharp Phillip A

Abstract excerpt

The POU domain transcription factors Oct-1 and Oct-2 interact with the octamer element, a motif conserved within Ig promoters and enhancers, and mediate transcription from the Ig loci. Inactivation of Oct-2 by gene targeting results in normal B cell development and Ig transcription. To study the role of Oct-1 in these processes, the lymphoid compartment of RAG-1(-/-) animals was reconstituted with Oct-1-deficient...

Topics

Adoptive Transfer
Animals
B-Lymphocytes
Cell Division
Cell Line, Transformed
DNA-Binding Proteins
Embryo, Mammalian
Gene Deletion
Gene Expression Regulation
Genes, RAG-1
Host Cell Factor C1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin Heavy Chains

Immunoglobulin Light Chains

Immunoglobulins

Mice

Mice, Knockout

Octamer Transcription Factor-1

Phenotype

Source

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Identifiers

PMID: 14762167
DOI: 10.1073/pnas.0307304101
PMCID: PMC357042

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B cell development and immunoglobulin transcription in Oct-1-deficient mice.PMID 14762167Read ↗

Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.Semantic proximity Read ↗

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