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Article

The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.

Molecular and cellular biology - 1 Mar 2001

Hess J, Nielsen P J, Fischer K D, Bujard H, Wirth T

Abstract excerpt

The transcriptional coactivator BOB.1/OBF.1 confers B-cell specificity on the transcription factors Oct1 and Oct2 at octamer site-containing promoters. A hallmark of the BOB.1/OBF.1 mutation in the mouse is the absence of germinal center development in secondary lymphoid organs, demonstrating the requirement for BOB.1/OBF.1 in antigen-dependent stages of B-cell differentiation. Here we analyzed earlier stages of...

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Identifiers

PMID: 11238890
DOI: 10.1128/MCB.21.5.1531-1539.2001
PMCID: PMC86699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.PMID 11238890Read ↗

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