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Article

Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.

Immunity - 1 Nov 1999

Tang H, Sharp P A

Abstract excerpt

Targeted disruption of either of the B cell-specific transcription factors Oct-2 or OCA-B/BOB-1/OBF-1 dramatically affects B cell terminal differentiation. The 3' enhancer of immunoglobulin heavy chain (IgH) locus is important for transcription of the locus in terminal plasma cells. Allele-specific suppression of mutant Oct-2 binding sites in this enhancer by a variant Oct-2 protein revealed that in a mature B...

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Identifiers

PMID: 10591177
DOI: 10.1016/s1074-7613(00)80127-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

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Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.PMID 10591177Read ↗

Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription.Semantic proximity Read ↗

B cell development and immunoglobulin transcription in Oct-1-deficient mice.Semantic proximity Read ↗

Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation.Semantic proximity Read ↗

Cutting edge: lack of peripheral B cells and severe agammaglobulinemia in mice simultaneously lacking Bruton's tyrosine kinase and the B cell-specific transcriptional coactivator OBF-1.Semantic proximity Read ↗

The OBF-1 gene locus confers B cell-specific transcription by restricting the ubiquitous activity of its promoter.Semantic proximity Read ↗

E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.Semantic proximity Read ↗

Critical role for the Oct-2/OCA-B partnership in Ig-secreting cells.Semantic proximity Read ↗

Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells.Semantic proximity Read ↗

The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Semantic proximity Read ↗

An IgH enhancer that drives transcription through basic helix-loop-helix and Oct transcription factor binding motifs. Functional analysis of the E(mu)3' enhancer of the catfish.Semantic proximity Read ↗

Complex regulation of the immunoglobulin mu heavy-chain gene enhancer: microB, a new determinant of enhancer function.Semantic proximity Read ↗

The B lymphocyte-specific coactivator BOB.1/OBF.1 is required at multiple stages of B-cell development.Semantic proximity Read ↗

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