Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.

doi:10.1016/s1074-7613(00)80127-2

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Article

Transcriptional regulation of the murine 3' IgH enhancer by OCT-2.

Immunity - 1 Nov 1999

Tang H, Sharp P A

Abstract excerpt

Targeted disruption of either of the B cell-specific transcription factors Oct-2 or OCA-B/BOB-1/OBF-1 dramatically affects B cell terminal differentiation. The 3' enhancer of immunoglobulin heavy chain (IgH) locus is important for transcription of the locus in terminal plasma cells. Allele-specific suppression of mutant Oct-2 binding sites in this enhancer by a variant Oct-2 protein revealed that in a mature B...

Topics

3' Untranslated Regions
Alleles
Animals
B-Lymphocytes
Cyclic AMP-Dependent Protein Kinases
DNA
DNA-Binding Proteins
Enhancer Elements, Genetic
Enzyme Inhibitors
Gene Expression Regulation
Genistein
Imidazoles
Immunoglobulin Heavy Chains
Isoquinolines

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipopolysaccharides

Lymphocyte Activation

Mice

Mice, Knockout

Source

Open in PubMed

Identifiers

PMID: 10591177
DOI: 10.1016/s1074-7613(00)80127-2

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