Article
Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice.
Molecular and cellular biology - 1 Feb 2004
Wang Victoria E H, Schmidt Tara, Chen Jianzhu, Sharp Phillip A, Tantin Dean
Abstract excerpt
Oct-1 is a sequence-specific DNA binding transcription factor that is believed to regulate a large group of tissue-specific and ubiquitous genes. Both Oct-1 and the related but tissue-restricted Oct-2 protein bind to a DNA sequence termed the octamer motif (5'-ATGCAAAT-3') with equal affinity in vitro. To address the role of Oct-1 in vivo, an Oct-1-deficient mouse strain was generated by gene targeting....
Topics
- Animals
- DNA-Binding Proteins
- Embryo Loss
- Erythropoiesis
- Gene Targeting
- Genes, Lethal
- Globins
- Heterozygote
- Host Cell Factor C1
- Mice
- Mutation
- Octamer Transcription Factor-1
- Octamer Transcription Factor-2
- Promoter Regions, Genetic