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Article

Ontogeny and localization of the cells produce IL-2 in healthy animals.

Cytokine - 1 Mar 2013

Yamamoto Mutsumi, Seki Yoichi, Iwai Kazuyuki, Ko Iei, Martin Alicia, Tsuji Noriko, Miyagawa Shuji, Love Robert B, Iwashima Makio

Abstract excerpt

IL-2 is a growth factor for activated T cells and is required for maintenance of naturally arising regulatory T cells (nTregs). Mice defective in IL-2/IL-2 receptor signaling pathways have impaired nTregs and suffer from lymphoproliferative disorders, suggesting that IL-2 is present and functional in healthy animals. However, the cellular source of IL-2 is currently unknown. To determine which cells produce IL-2...

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Identifiers

PMID: 23332616
DOI: 10.1016/j.cyto.2012.11.026
PMCID: PMC3595346

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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