Mice with a fluorescent marker for interleukin 2 gene activation.

doi:10.1016/s1074-7613(00)80603-2

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Article

Mice with a fluorescent marker for interleukin 2 gene activation.

Immunity - 1 Aug 1998

Naramura M, Hu R J, Gu H

Abstract excerpt

Production of interleukin (IL)-2 by T lymphocytes is one of the earliest events during immune response. A mutant mouse strain was generated by replacing the IL-2 gene with a cDNA encoding green fluorescent protein (GFP). In this model, GFP fluorescence is readily detectable upon T cell activation...

Topics

Alleles
Animals
CD4-Positive T-Lymphocytes
Cell Differentiation
Gene Expression Regulation
Genes, Reporter
Green Fluorescent Proteins
Indicators and Reagents
Interleukin-2
Luminescent Proteins
Lymphocyte Activation
Mice
Mice, Transgenic
Transcriptional Activation

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