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Article

Mice with a fluorescent marker for interleukin 2 gene activation.

Immunity - 1 Aug 1998

Naramura M, Hu R J, Gu H

Abstract excerpt

Production of interleukin (IL)-2 by T lymphocytes is one of the earliest events during immune response. A mutant mouse strain was generated by replacing the IL-2 gene with a cDNA encoding green fluorescent protein (GFP). In this model, GFP fluorescence is readily detectable upon T cell activation and is mostly coexpressed with IL-2 at the single cell level. Thus, individual activated T cells can express the IL-2...

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PMID: 9729041
DOI: 10.1016/s1074-7613(00)80603-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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