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Article

The role of erk1 and erk2 in multiple stages of T cell development.

Immunity - 1 Oct 2005

Fischer April M, Katayama Carol D, Pagès Giles, Pouysségur Jacques, Hedrick Stephen M

Abstract excerpt

Activation of extracellular-signal-regulated protein kinase (Erk) is central to growth-factor-receptor-mediated signaling including that originating from the T cell antigen receptor. It integrates cytoplasmic signals to effect changes in transcription associated with differentiation, proliferation, and survival. In this report, we present an analysis of mice with targeted deletions in Erk1 and Erk2 to assess the...

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Identifiers

PMID: 16226508
DOI: 10.1016/j.immuni.2005.08.013

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