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Article

Oocyte polarity depends on regulation of gurken by Vasa.

Development (Cambridge, England) - 1 May 1998

Tomancak P, Guichet A, Zavorszky P, Ephrussi A

Abstract excerpt

Vasa, a DEAD box mRNA helicase similar to eIF4A, is involved in pole plasm assembly in the Drosophila oocyte and appears to regulate translation of oskar and nanos mRNAs. However, several vasa alleles exhibit a wide range of early oogenesis phenotypes. Here we report a detailed analysis of Vasa function during early oogenesis using novel as well as previously identified hypomorphic vasa alleles. We find that vasa...

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Source

Identifiers

PMID: 9521910
DOI: 10.1242/dev.125.9.1723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oocyte polarity depends on regulation of gurken by Vasa.PMID 9521910Read ↗

<i>vasa</i> is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst developmentSemantic proximity Read ↗

Requirement for the vasa RNA helicase in gurken mRNA localization.Semantic proximity Read ↗

VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS.Semantic proximity Read ↗

A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin.Semantic proximity Read ↗

Interaction with eIF5B is essential for Vasa function during development.Semantic proximity Read ↗

Translational repressor bruno plays multiple roles in development and is widely conserved.Semantic proximity Read ↗

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos.Semantic proximity Read ↗

Maternal Nanos and Pumilio regulate zygotic vasa expression autonomously in the germ-line progenitors of Drosophila melanogaster embryos.Semantic proximity Read ↗

Oocyte determination and the origin of polarity in Drosophila: the role of the spindle genes.Semantic proximity Read ↗

The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.Semantic proximity Read ↗

maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA.Semantic proximity Read ↗

Zebrafish vasa is required for germ-cell differentiation and maintenance.Semantic proximity Read ↗

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