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Article

Translational repressor bruno plays multiple roles in development and is widely conserved.

Genes & development - 1 Oct 1997

Webster P J, Liang L, Berg C A, Lasko P, Macdonald P M

Abstract excerpt

oskar (osk) mRNA is tightly localized to the posterior pole of the Drosophila oocyte, where the subsequent expression of Osk protein directs abdomen and germ-line formation in the developing embryo. Misplaced expression of Osk protein leads to lethal body patterning defects. The Osk message is translationally repressed before and during the localization process, ensuring that Osk protein is only expressed after...

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Identifiers

PMID: 9334316
DOI: 10.1101/gad.11.19.2510
PMCID: PMC316560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Translational repressor bruno plays multiple roles in development and is widely conserved.PMID 9334316Read ↗

Translational regulation of oskar mRNA by bruno, an ovarian RNA-binding protein, is essential.Semantic proximity Read ↗

Region-specific activation of oskar mRNA translation by inhibition of Bruno-mediated repression.Semantic proximity Read ↗

oskar RNA plays multiple noncoding roles to support oogenesis and maintain integrity of the germline/soma distinction.Semantic proximity Read ↗

Two distinct domains of Bruno bind specifically to the oskar mRNA.Semantic proximity Read ↗

Apontic binds the translational repressor Bruno and is implicated in regulation of oskar mRNA translation.Semantic proximity Read ↗

A late phase of Oskar accumulation is crucial for posterior patterning of the Drosophila embryo, and is blocked by ectopic expression of Bruno.Semantic proximity Read ↗

Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis.Semantic proximity Read ↗

RNA sequences required for the noncoding function of oskar RNA also mediate regulation of Oskar protein expression by Bicoid Stability Factor.Semantic proximity Read ↗

Oocyte polarity depends on regulation of gurken by Vasa.Semantic proximity Read ↗

Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta.Semantic proximity Read ↗

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.Semantic proximity Read ↗

Multiple cis-acting signals, some weak by necessity, collectively direct robust transport of oskar mRNA to the oocyte.Semantic proximity Read ↗

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