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Article

Interaction with eIF5B is essential for Vasa function during development.

Development (Cambridge, England) - 1 Sept 2004

Johnstone Oona, Lasko Paul

Abstract excerpt

The DEAD-box RNA helicase Vasa (Vas) is required for germ cell development and function, as well as for embryonic somatic posterior patterning. Vas interacts with the general translation initiation factor eIF5B (cIF2, also known as dIF2), and thus may regulate translation of specific mRNAs. In order to investigate which functions of Vas are related to translational control, we have analyzed the effects of...

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Identifiers

PMID: 15280213
DOI: 10.1242/dev.01286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction with eIF5B is essential for Vasa function during development.PMID 15280213Read ↗

VASA mediates translation through interaction with a Drosophila yIF2 homolog.Semantic proximity Read ↗

Oocyte polarity depends on regulation of gurken by Vasa.Semantic proximity Read ↗

<i>vasa</i> is required for GURKEN accumulation in the oocyte, and is involved in oocyte differentiation and germline cyst developmentSemantic proximity Read ↗

Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Semantic proximity Read ↗

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.Semantic proximity Read ↗

Functional dissection of the RNA signal sequence responsible for vegetal localization of XGrip2.1 mRNA in Xenopus oocytes.Semantic proximity Read ↗

Evolutionary conserved role of eukaryotic translation factor eIF5A in the regulation of actin-nucleating formins.Semantic proximity Read ↗

VASA localization requires the SPRY-domain and SOCS-box containing protein, GUSTAVUS.Semantic proximity Read ↗

Requirement for the vasa RNA helicase in gurken mRNA localization.Semantic proximity Read ↗

A second maternally expressed Drosophila gene encodes a putative RNA helicase of the "DEAD box" family.Semantic proximity Read ↗

Translational repressor bruno plays multiple roles in development and is widely conserved.Semantic proximity Read ↗

eIF4A RNA Helicase Associates with Cyclin-Dependent Protein Kinase A in Proliferating Cells and Is Modulated by Phosphorylation.Semantic proximity Read ↗

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