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Article

The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.

Development (Cambridge, England) - 1 Dec 2005

Steinhauer Josefa, Kalderon Daniel

Abstract excerpt

The heterogeneous nuclear ribonucleoprotein (hnRNP) Squid (Sqd) is a highly abundant protein that is expected to bind most cellular RNAs. Nonetheless, Sqd plays a very specific developmental role in dorsoventral (DV) axis formation during Drosophila oogenesis by localizing gurken (grk) RNA. Here, we report that Sqd is also essential for anteroposterior (AP) axis formation. We identified sqd in a screen for...

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Identifiers

PMID: 16291786
DOI: 10.1242/dev.02159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The RNA-binding protein Squid is required for the establishment of anteroposterior polarity in the Drosophila oocyte.PMID 16291786Read ↗

Squid is required for efficient posterior localization of oskar mRNA during Drosophila oogenesis.Semantic proximity Read ↗

Initial organization of the Drosophila dorsoventral axis depends on an RNA-binding protein encoded by the squid gene.Semantic proximity Read ↗

Squid, Cup, and PABP55B function together to regulate gurken translation in Drosophila.Semantic proximity Read ↗

Specific isoforms of squid, a Drosophila hnRNP, perform distinct roles in Gurken localization during oogenesis.Semantic proximity Read ↗

The RNA-binding protein Tsunagi interacts with Mago Nashi to establish polarity and localize oskar mRNA during Drosophila oogenesis.Semantic proximity Read ↗

Anterior-posterior axis specification in Drosophila oocytes: identification of novel bicoid and oskar mRNA localization factors.Semantic proximity Read ↗

Repression of Gurken translation by a meiotic checkpoint in Drosophila oogenesis is suppressed by a reduction in the dose of eIF1A.Semantic proximity Read ↗

The identification of novel genes required for Drosophila anteroposterior axis formation in a germline clone screen using GFP-Staufen.Semantic proximity Read ↗

The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila.Semantic proximity Read ↗

The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification.Semantic proximity Read ↗

Hrb27C, Sqd and Otu cooperatively regulate gurken RNA localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis.Semantic proximity Read ↗

Homeless is required for RNA localization in Drosophila oogenesis and encodes a new member of the DE-H family of RNA-dependent ATPases.Semantic proximity Read ↗

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