Article
Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action.
The Journal of biological chemistry - 4 Jun 2004
Zabolotny Janice M, Haj Fawaz G, Kim Young-Bum, Kim Hyo-Jeong, Shulman Gerald I, Kim Jason K, Neel Benjamin G, Kahn Barbara B
Abstract excerpt
Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and humans. Overexpression of LAR selectively in muscle of transgenic mice causes whole body insulin resistance. To determine whether overexpression of...
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