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Article

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.

Nature medicine - 1 Feb 2005

Sleeman Mark W, Wortley Katherine E, Lai Ka-Man V, Gowen Lori C, Kintner Jennifer, Kline William O, Garcia Karen, Stitt Trevor N, Yancopoulos George D, Wiegand Stanley J, Glass David J

Abstract excerpt

Genetic ablation of Inppl1, which encodes SHIP2 (SH2-domain containing inositol 5-phosphatase 2), was previously reported to induce severe insulin sensitivity, leading to early postnatal death. In the previous study, the targeting construct left the first eighteen exons encoding Inppl1 intact, generating a Inppl1(EX19-28-/-) mouse, and apparently also deleted a second gene, Phox2a. We report a new SHIP2 knockout...

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Identifiers

PMID: 15654325
DOI: 10.1038/nm1178

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.PMID 15654325Read ↗

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