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Article

Increased hepatic insulin sensitivity in mice lacking inhibitory leptin receptor signals.

Endocrinology - 1 Jun 2011

Tom Robby Zachariah, Sjögren Rasmus J O, Vieira Elaine, Glund Stephan, Iglesias-Gutiérrez Eduardo, Garcia-Roves Pablo M, Myers Martin G, Björnholm Marie

Abstract excerpt

Leptin regulates food intake and energy expenditure by activating the long form of the leptin receptor (LepRb). Leptin also regulates glucose homeostasis by improving whole-body insulin sensitivity, but the mechanism remains undefined. Leptin action is mediated by phosphorylation of several tyrosine residues on LepRb. LepRb-Tyr985 plays an important role in the attenuation of LepRb signaling. We determined the...

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Identifiers

PMID: 21521753
DOI: 10.1210/en.2010-0040

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