Article
Visceral obesity without insulin resistance in late-onset obesity rats.
Endocrinology - 1 Jun 2004
Bains Randip K, Wells Sara E, Flavell Dave M, Fairhall Keith M, Strom Molly, Le Tissier Paul, Robinson Iain C A F
Abstract excerpt
We describe a line of transgenic rats in which the males develop a unique autosomal dominant, late-onset obesity (LOB) phenotype. LOB males gradually accumulate fat specifically in visceral, but not peripheral, fat depots despite a normal intake of a low fat diet. LOB females normally develop only mild obesity with advanced age. However, the phenotype can be induced rapidly in young females by ovariectomy and...
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