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Article

Delineation of selective influences shaping the mutated expressed human Ig heavy chain repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 1998

Dörner T, Brezinschek H P, Foster S J, Brezinschek R I, Farner N L, Lipsky P E

Abstract excerpt

After Ag exposure, somatic hypermutation and subsequent selection play significant roles in shaping the peripheral B cell repertoire. However, the disparate impact of each process has not been completely delineated. To address this, the mutational patterns of a large panel of productive V(H)DJ(H) rearrangements of individual human B cells were analyzed and compared with those of a previously reported panel of...

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Identifiers

PMID: 9510186

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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