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Article

Targeting and subsequent selection of somatic hypermutations in the human V kappa repertoire.

European journal of immunology - 1 Oct 1999

Foster S J, Dorner T, Lipsky P E

Abstract excerpt

The number and distribution of nucleotide substitutions in human VkappaJkappa genes were examined using a PCR technique that analyzed nonproductive and productive rearrangements amplified from genomic DNA of individual B cells. The results indicate that the mutational mechanism introduces replacement (R) mutations comparably throughout the length of the VkappaJkappa rearrangement, but tends to target specific...

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Source

Identifiers

PMID: 10540323
DOI: 10.1002/(SICI)1521-4141(199910)29:10<3122::AID-IMMU3122>3.0.CO;2-O

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Source receipt: pubmed, retrieved 7 Sept 2026.

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