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Article

Bias in somatic hypermutation of human VH genes.

International immunology - 1 Sept 1994

Insel R A, Varade W S

Abstract excerpt

Translationally silent mutations, which are not antigen selected, of human VH6 Ig gene rearrangements isolated from human spleen were analyzed for bias to gain insight into intrinsic features of the mutation process. Sixty-three clones representing 38 VH6DJ rearrangements had an overall mutation...

Topics

B-Lymphocytes
Base Sequence
Child
Child, Preschool
Clone Cells
DNA
Female
Gene Rearrangement
Genes, Immunoglobulin
Humans
Hybrid Cells
Immunoglobulin Variable Region
Immunoglobulins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Molecular Sequence Data

Mutation

Spleen

Source

Identifiers

PMID: 7819153
DOI: 10.1093/intimm/6.9.1437

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7819153-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Bias in somatic hypermutation of human VH genes.PMID 7819153Read ↗

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