Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bias in somatic hypermutation of human VH genes.

International immunology - 1 Sept 1994

Insel R A, Varade W S

Abstract excerpt

Translationally silent mutations, which are not antigen selected, of human VH6 Ig gene rearrangements isolated from human spleen were analyzed for bias to gain insight into intrinsic features of the mutation process. Sixty-three clones representing 38 VH6DJ rearrangements had an overall mutation frequency of 4.5%, a replacement/silent (R/S) mutation ratio of 2.1 and 167 unique silent mutations. The silent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Base Sequence
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Clone Cells

Share to Molecular Sequence Data

Share to Mutation

Source

Identifiers

PMID: 7819153
DOI: 10.1093/intimm/6.9.1437

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bias in somatic hypermutation of human VH genes.PMID 7819153Read ↗

Strong intrinsic biases towards mutation and conservation of bases in human IgV<sub>H</sub> genes during somatic hypermutation prevent statistical analysis of antigen selectionSemantic proximity Read ↗

Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes.Semantic proximity Read ↗

B cell variable genes have evolved their codon usage to focus the targeted patterns of somatic mutation on the complementarity determining regions.Semantic proximity Read ↗

Somatic hypermutation in immunity and cancer: Critical analysis of strand-biased and codon-context mutation signatures.Semantic proximity Read ↗

High frequency of somatically mutated IgM molecules in the human adult blood B cell repertoire.Semantic proximity Read ↗

Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.Semantic proximity Read ↗

Use of the most JH-proximal human Ig H chain V region gene, VH6, in the expressed immune repertoire.Semantic proximity Read ↗

Age-related impaired affinity maturation and differential D-JH gene usage in human VH6-expressing B lymphocytes from healthy individuals.Semantic proximity Read ↗

The targeting of somatic hypermutation.Semantic proximity Read ↗

The pattern and distribution of immunoglobulin VH gene mutations in chronic lymphocytic leukemia B cells are consistent with the canonical somatic hypermutation process.Semantic proximity Read ↗

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine DesignSemantic proximity Read ↗

Comparison of the human germline and rearranged VH repertoire reveals complementarity between germline variability and somatic mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.