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Article

Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.

1 Oct 1993

Abstract excerpt

Polyreactive (natural) antibodies are primarily IgM and account for a major proportion of circulating Ig in humans. They use various V gene segments, in general, in germ line (unmutated) configuration. To analyze the VH regions of polyreactive antibodies, with particular attention at their somatically mutated status, we generated five IgG (three IgG1 and two IgG3) mAb (using B cells from a healthy subject, a...

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Identifiers

PMID: 8376796
DOI: 10.4049/jimmunol.151.7.3604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Structural analysis of the VH-D-JH segments of human polyreactive IgG mAb. Evidence for somatic selection.PMID 8376796Read ↗

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