Analysis of the targeting of the hypermutational machinery and the impact of subsequent selection on the distribution of nucleotide changes in human VHDJH rearrangements.

Abstract excerpt

B cells are unique in that they generate and tolerate a high rate of mutations in their antigen receptor genes and employ these mutations as a basis of avidity maturation. The precise role of the mutational machinery versus subsequent selection in determining the frequency and distribution of mutations has not been fully analyzed. To address these issues, the influence of the intrinsic mutational machinery and...

Topics

• B-Lymphocytes
• Base Sequence
• Codon
• Gene Rearrangement
• Humans
• Immunoglobulin Heavy Chains
• Immunoglobulin J-Chains
• Immunoglobulin Variable Region
• Immunoglobulin delta-Chains
• Molecular Sequence Data
• Mutation