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Article

Enhanced evolvability in immunoglobulin V genes under somatic hypermutation.

Journal of molecular evolution - 1 Jul 1999

Cowell L G, Kim H J, Humaljoki T, Berek C, Kepler T B

Abstract excerpt

Darwinian theory requires that mutations be produced in a nonanticipatory manner; it is nonetheless consistent to suggest that mutations that have repeatedly led to nonviable phenotypes would be introduced less frequently than others-if under appropriate genetic control. Immunoglobulins produced...

Topics

Arthritis
Arthritis, Rheumatoid
DNA, Complementary
Evolution, Molecular
Gene Frequency
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Mutation
Selection, Genetic
Serine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10368430
DOI: 10.1007/pl00006530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-10368430-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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