Article

Molecular Mechanisms and Selection Influence the Generation of the Human VλJλ Repertoire

1999-02-01

Abstract excerpt

Abstract To define the λ light chain repertoire in humans, a single-cell PCR technique using genomic DNA obtained from individual peripheral B cells was employed. Of the 30 known functional Vλ genes, 23 were detected in either the nonproductive or productive repertoires. Specific Vλ genes, including 2A2, 2B2, 1G, and 4B, were overexpressed in the nonproductive repertoire, whereas some Vλ genes, such as 3R, 2A2, 2B...

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Literature Corpus work: 36cfa967-0a18-5d23-bf2b-af4f51a8d72e
DOI: 10.4049/jimmunol.162.4.2137

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